High Throughput Screening in 2D and 3D models: from drug discovery to patient stratification

Explore the advanced OncoSignature High Throughput Screening (HTS) platform with Dr David Sorrell and Dr Tim Scales from Horizon Discovery™ in this detailed video.

They cover how both 2D and 3D cell culture formats are utilised for cell-based screening.

The OncoSignature 2D panel features 300 diverse and well-characterised cancer cell lines, which are profiled with compounds as single or combination therapies to measure antiproliferative effects using the luminescent CellTiter-Glo 2.0® Assay.

This approach is crucial for identifying drug responses, aiding patient stratification, and accelerating the drug development process.

The video also introduces OncoSignature 3D Services, which use the CellTiter-Glo®3D reagent designed for complex 3D microtissues, to provide insights into drug responses in more physiologically relevant models. Learn about the benefits of employing both 2D and 3D spheroid-based assay formats in drug discovery and their integration into an automated HTS platform.